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While selection and safety establish who to treat and how to minimize risks, response biomarkers evaluate whether the intervention produces meaningful benefit, mirroring how preclinical glial modulation must be validated through functional readouts

The placebo group gained back nearly 21 pounds while the orforglipron group stayed essentially flat

Beutler E, Moroose R, Kramer L, Gelbart T, Forman L: Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia

Side effects are similar as well, although some patients like it better and some like it worse. Reasons People May Want to Switch To Avoid Needles For some patients, this is the entire story