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Several randomised trials (STEP) [1215] have compared outcomes following weekly subcutaneous administration of semaglutide to both placebo and lifestyle modification in patients mostly without diabetes with overweight/ obesity

Some research suggests that weight loss in men with obesity and type 2 diabetes may actually improve testosterone levels and sexual function over time, as excess adipose tissue can contribute to hormonal imbalances

Rybelsus (semaglutide) is an oral GLP-1 receptor agonist licensed in the UK for type 2 diabetes

Diarrhea 29.7% of participants in research studying the gastrointestinal tolerability in patients taking semaglutide experienced diarrhea