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Other studies and systematic reviews, however, did not find any benefits from using minocycline as adjunctive therapy in patients with BD [320, 321], and contrary to some proposals, doxycycline exposure in the adolescence did not report any causal relationship between this tetracycline and BD development [322]

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Prog Neuropsychopharmacol Biol Psychiatry 2004;28:181-90

A B12 injection may be worth discussing if: You have absorption problems: Conditions like Crohn's disease, celiac disease, or atrophic gastritis can reduce how well your body absorbs B12 from food, and past gastric surgery can have a similar effect