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It has been reported that the lack of glutamic acid decarboxylase (GAD), which controls GABA synthesis, can cause neurological diseases

Although insulin suppresses both GAL and NPY expression, leptin strongly inhibits NPY gene expression and release, yet produces little or no change in basal GAL expression in the ARC and only a small suppression of GAL expression in the PVN

Additionally, rapid weight loss in general can promote breakdown of both fat and muscle unless muscle is actively preserved through nutrition and resistance training

Alla luce dei risultati ottenuti, gli autori italiani invitano alla prudenza e sottolineano la necessit di nuovi studi per chiarire il nesso causale tra questi farmaci e le ideazioni suicidarie