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Beyond Ozempic: New GLP-1 drugs promise weight loss and health benefits

Reported plasma levels of phenformin after 50-100 mg of phenformin uptake in patients are ~1.7 M 67 , while tissue concentrations have not been assessed but are expected to be much higher as reported in animal models 68

Lactylation and tumor stroma interaction Lactate seeps into the surrounding stroma and stamps a chemical tag called lysine lactylation on stromal chromatin, rewiring how blood vessels, fibroblasts and immune barriers are built

It is important to note that regulatory bodies including the MHRA and EMA continue to monitor the safety profile of GLP-1 receptor agonists, including any potential psychiatric effects