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Zinc dysregulation within the endolysosomal system also intersects with cancer biology: the alcohol-deterrent and emerging anticancer agent disulfiram disrupts endolysosomal structure and raises intraluminal zinc in breast cancer cells, implicating zinc dysregulation in its cytotoxicity and suggesting that extracellular zinc availability modulates its efficacy 169

RPS can inhibit tumor growth by inducing cell cycle arrest [39], regulating metabolism pathways [40], modulating DNA methylation [41], and regulating the Wnt/-catenin [42] and MAPK signaling pathways [43]

English language version of the S3-consensus guidelines on chronic pancreatitis: Definition, aetiology, diagnostic examinations, medical, endoscopic and surgical management of chronic pancreatitis

The landmark Rudman study demonstrated that GH restoration in older men produced significant improvements in lean mass, fat mass, and skin thickness (9)