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Introduction Autism spectrum disorder (ASD) is a highly polygenic developmental condition characterized by alterations in social communication and interaction, and restricted patterns of behaviors, interests, and activities 1,2

Concurrently, total brain ferritin levels are decreased despite elevated ferritin deposition in the substantia nigra, where an increased ferritin heavy chain-to-light chain ratio is associated with reduced iron storage stability (Friedman and Galazka-Friedman, 2012)