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These include improved DNA repair (through PARP, another NAD+-dependent enzyme), enhanced autophagy (cellular cleanup), reduced inflammation, and mitochondrial quality control

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In this cMAK algorithm, the transcriptional, proteomic, and phosphoproteomic data of predicted kinases were wholly considered to reduce potentially false-positive hits, and predicted kinases with differentially regulated mRNAs at 2 time points, changed proteins at 1 time point, or altered phosphorylation sites at 1 time point were retained

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