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Subsequent studies, however, led to the notion that DBS mechanisms were more complicated, also activating outputs from the stimulated structure, leading to widespread modulation of basal ganglia-thalamocortical circuits and improving the downstream effects of dopaminergic deficiency in a non-chemical manner 60,61,62,63,64

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Because it affects only GH secretion in isolation and has virtually no side effects on the body, it is often considered a "gentle" peptide and allows the isolated effects of selective action on GH stimulation to be investigated

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