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In healthy subjects, metformin significantly decreased the levels of S1P, a bioactive lipid generated by converting ceramide to sphingosine

About one-fifth of them were taking one of the following GLP-1 drugs: semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), exenatide (Byetta, Bydureon), or dulaglutide (Trulicity)

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[DOI] [PMC free article] [PubMed] [Google Scholar] [130].Zaic S, Krajnc N, Macher S, Michl M, Mller N, Mitsch C, et al