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Lastly, in general there were similar labelling patterns when gdh3 / gdh3 mutants were compared with the wild-type strain grown on proline as when gdh3 / gdh3 cells grown in proline and in arginine media were compared (column 1 and column 3 in Fig

Pasco JA, Jacka FN, Williams LJ, Henry MJ, Nicholson GC, Kotowicz MA, et al

Excessive NNMT activity can lead to a reduction in NAD+ and SAM levels

For example, the general applications of adeno-associated virus-based gene therapy are hampered by pre-existing humoral immune responses against the viral vectors [350,351,352], which for some viral serotypes occur in up to 60% of the population because of early-life infections [353, 354]