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A 2024 meta-analysis of 35 RCTs found selenium supplementation significantly reduced TPO antibodies, TSH, and oxidative stress markers in Hashimoto's patients - effects mediated through the GPx-glutathione system

A 2012 study published in Current Medicinal Chemistry reported that children with autism consistently "had decreased glutathione levels due to high oxidative stress"

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What this evidence means for healthcare professionals Supporting thyroid physiology in the subclinical stage Taken together, the available studies describe a consistent direction of effect in patients with subclinical hypothyroidism and thyroid autoimmunity