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Current evidence doesnt point to a specific causal relationship that directly links GLP-1 drugs and microbial overgrowths, but the underlying mechanics and possible resulting effects certainly warrant a degree of caution

The PK and PD studies for assessment of possible DDI between warfarin and GLP1RA were conducted for exenatide [25], lixisenatide [31], albiglutide [14], dulaglutide [15] and semaglutide [16] (Table 2)

This prevention signal, if confirmed in prospective studies, would have enormous implications for high-risk populations