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Transcripts per million (TPM) generation and differential expression analysis was performed on aligned reads to Mus musculus UCSC GRCm38/mm10 reference genome using Illumina RNA-seq differential expression software (DESeq2, v1.0.1) 54

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Experimental findings indicate that a primary downstream target of GLP-1R signalling is FOXO1 , an essential transcription factor crucial for GC apoptosis and cell cycle control

A comprehensive review of clinical trials from 2021 highlights that once-weekly subcutaneous semaglutide (1 mg) consistently lowered HbAc by 1.5 to 1.8% over 30 to 56 weeks, outperforming other medications including sitagliptin, dulaglutide, and insulin glargine in the SUSTAIN series.33 Real-world data from 2023 further support these findings, showing an average HbA1c reduction of approximately 0.9% and a fasting blood glucose decrease of 26 mg/dL after six months of once-weekly semaglutide use.34 These results underscore semaglutides ability to offer meaningful improvements in glycemic control and metabolic health for patients with T2DM