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Therefore, caution should be exercised to prevent hypoglycemia when adding incretin-based therapy to pre-existing sulfonylurea therapy in patients with type 2 diabetes

GHK (Gly-His-Lys) without copper is a simple tripeptide with a strong affinity for Cu(II) ions (log stability constant ~16.2), while GHK-Cu is the pre-formed 1:1 copper-peptide complex with distinct biological activity profiles

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Although we performed multivariate adjustments, residual confounding may persist due to unmeasured factors such as dietary habits (e.g., irregular intake of animal-derived foods or B12-fortified products), unrecorded use of nutritional supplements, and genetic predispositionsparticularly MTHFR polymorphisms, which are known to influence homocysteine metabolism and folate cycling, thereby potentially altering the functional demand for vitamin B12