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doi: 10.1016/j.ymben.2015.08.007

Understanding cartilage protection in OA and injury: A spectrum of possibilities

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To this end, we performed a small-scale screening of commercially available sterol metabolites/derivatives as potential modulators of ferroptosis, which include those that influence SREBP/SCAP transport from the endoplasmic reticulum to Golgi (25- and 27- hydroxycholesterol, denoted as 25-HC and 27-HC respectively), intermediates of cholesterol biosynthesis that control protein stabilities of HMGCR and SQLE, two rate-limiting enzymes for cholesterol biosynthesis (desmosterol (Desmo), cholesterol (CH), lanosterol (Lano) and 24, 25-dihydrolanosterol(24,25D-Lano)) 26 , direct precursor to cholesterol (7-DHC), as well as other sterols/oxysterols that may regulate cholesterol metabolism (zymosterol (Zymo) and lathosterol (Lano))