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R., Medvedev, S., Schultz, R
Synapse 18:2126 Porcheray F, Samah B, Leone C, Dereuddre-Bosquet N, Gras G (2006a) Macrophage activation and human immunodeficiency virus infection: HIV replication directs macrophages towards a pro-inflammatory phenotype while previous activation modulates macrophage susceptibility to infection and viral production
In a related rat model, activation of p62/Nrf2 and downregulation of ROS were also observed, as evidenced by reductions in arthritis scores and pathological features (marked infiltration of inflammatory cells, synovial hyperplasia, cartilage damage and bone destruction), as well as inhibition of NFATc1 and other osteoclast activities and bone resorption regulators (CTSK and MMP-9)
