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Mechanisms biologically plausible based on known growth factor and healing pathways

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During the condensation of farnesylpyrophosphates to squalene, the enzyme farnesyl-diphosphate farnesyltransferase 1 (commonly called squalene synthase) utilizes a mole of NADPH during the reduction of a carbon-carbon double bond (-C=C-)

Moreover, the observed overexpression of secretory stage specific markers PAEP, SPP1 and LIF may contribute to impaired endometrial receptivity, potentially underlying adenomyosis-associated infertility [75,76,77]