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What we know Binge drinking (more than five drinks on a single occasion) and chronic, high alcohol consumption (more than two drinks/day) are associated with an increased risk of atrial fibrillation

Similarly, the research team found that membrane G protein-coupled bile acid receptor 5 (TGR5) enhances mitophagy and inhibits mitochondrial fission by regulating the PKC /Drp1-HK2 signaling pathway in HG-induced human retinal endothelial cells (RMEC) and STZ induced SD rat models, thus having a certain therapeutic effect on retinal dysfunction [160]

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Novel insight into the molecular make-up of AMYRs and central signaling reinforces its key function in modulating homeostatic and hedonic feeding mechanisms