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Conclusions Confirmation of bioequivalence in the present study provides support that the safety profile and efficacy of each dose level of once-daily 2G oral semaglutide (1.5, 4 and 9 mg), in terms of reductions in HbA 1c and body weight, will be equivalent to the corresponding dose level of once-daily 1G oral semaglutide (3, 7 and 14 mg), therefore allowing switching from the 1G to the 2G formulation

As of December 2025, Medicare does not cover GLP-1s for weight loss, and several state Medicaid programs rolled back coverage in 2025

Novo is also in the midst of a legal fight in the country over the patent

It is not approved for the treatment of Type 1 diabetes and is not to be started by individuals with current or past pancreatitis