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Mechanistically, liraglutide administration inhibited the upregulation of pain-related markers in the TNC, including calcitonin gene-related peptide (CGRP), c-fos, and components of the PI3K/Akt signaling pathway [94]

But during large clinical trials, researchers noticed something unexpected patients were having fewer heart attacks, fewer heart failure hospitalizations, and their kidneys were staying healthier for longer

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