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KPV has not been tested in pregnancy, breastfeeding, or in people on immune-modifying drugs, so those groups fall outside the evidence and have the most reason for caution

Natl Acad Sci Lett (2007) 30(7-8):24750

Complicated UTIs happen when there are extra risks involved, such as: Blockages in the urinary tract, like kidney stones Catheters or other medical devices in the urinary system Underlying health conditions like diabetes or a weak immune system Structural problems in the urinary tract Recent urinary tract surgery These factors make the infection more serious and sometimes harder to cure

Human subjects Pancreata and islets from non-diabetic adult donors were obtained via a partnership with CORE (Center for Organ Recovery and Education)