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Regardless, patients with TDP-43 mutations have TDP-43 pathology, and the mouse model that have A315T mutation has TDP-43 accumulations mostly in the nucleus, have extensive ubiquitinated protein accumulations in the cytoplasm, and based on the antibody used, pTDP-43 are also detected in the cytoplasm 19,46

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BBB disruption in age and neurodegenerative disorders Disruption of the BBB coincides with healthy aging, but the characteristics of breakdown can become further exacerbated in neurodegenerative disorders (Table 1)

A clear vial can still have lost quality or sterility history