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GLP-1RAs also exert anti-arrhythmic effects via reducing calcium leak from the sarcoplasmic reticulum in ventricular arrhythmia, which has the potential to decrease phosphorylation of the type 2 ryanodine receptor (RyR2) and alleviate the activity of CaMK-II [77]

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The GLP-1 peptide is a naturally occurring hormone produced by the gut that sends signals to the brain affecting metabolism and appetite