Illustratively, BPC 157 counteracted lidocaine convulsions [60], and thereby, likely also lidocaines effects on the central nervous system (i.e., inhibiting nicotinic acetylcholine receptors, inhibiting presynaptic calcium channels in the dorsal root ganglion, inhibiting opioid receptors, inhibiting of neurite growth, inhibiting muscarinic cholinergic receptors, and preventing substance P from binding to natural killer (NK) cell receptors) [278,281,282,283]
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BPC-157 and its impact on GABA The peptide BPC-157 has a direct effect on the regeneration of the GABA system, while simultaneously accelerating the return to homeostasis after addiction or abuse of drugs and substances that directly damage the GABA system
Multicenter, large-scale, randomized, controlled studies are necessary to fully establish the efficacy of the available treatments