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GHD is much worse in children who received radiation for brain tumors than for the other tumors ( Studies addressed that hGH had a radio-protective effect both in vivo and in vitro possibly due to DNA repairing mechanisms

Contemporary research has provided evidence that heat stress has detrimental effects on oocytes, mediated by heat-induced molecular alterations, including mitochondrial dysfunction, elevated oxidative stress, and impaired DNA integrity within both the oocyte and its surrounding follicular microenvironment [85]

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