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Researchers originally became interested in DSIP because of its connection to deep sleep cycles, particularly delta wave sleep, which is the most restorative phase of sleep

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47 Among the various conservative treatments proposed, the restriction or suspension of physical activity (in particular activities involving pivoting, jumping and repetitive impacts) seems to be of primary importance

Subsequently, in 2019, the Food and Drug Administration (FDA) approved the S-enantiomer of ketamine, esketamine, for patients with treatment-resistant depression