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Differences were observed in the case of epithelial cells

Inhibitors of the sodium-glucose cotransporter 2 (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) have been studied and trialled in type 2 diabetes with an overwhelming body of evidence supporting their use in type 2 diabetes [10]

While hormonal changes and a diminishing ovarian reserve of oocytes, contribute to this decline, evidence indicates that the major driver of reduced fecundity in AMA is the progressive deterioration of oocyte quality, largely mediated by oxidative stress [11,12,13,14]

Therefore, regulatory authorities required additional pharmacovigilance activities, by systematically monitoring the annual incidence of MTC in the US for at least 15 years (MTC-22341, results expected by 20352037)