incretin hormone glp-1 hormones and the satiation signal GLP-1 Genetics: How Genes Affect

Family members and carers play a vital role in monitoring for subtle changes that patients themselves may not recognise, particularly in the early weeks of treatment

Persistent or worsening symptoms despite dietary modifications and over-the-counter interventions lasting more than 2-3 weeks should be discussed with your prescribing clinician, as this may indicate inadequate tolerance to the current dose or the need for alternative management strategies

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Patients should be aware that severe or progressive cold intolerance especially when accompanied by significant fatigue, constipation, dry skin, hair loss, or unexplained weight gain despite continued GLP-1 therapywarrants investigation for hypothyroidism or other conditions