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If you dont understand the biochemical pathway of the thing youre megadosing, you are not a candidate. He tells the thiamine story: woman with zero energy gets put on 1100 mg a day when the RDA is ~1.3 mg

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[PubMed] 218.Dias-Ferreira J, Fernandes AR, Soriano JL, Naveros BC, Severino P, da Silva CF, et al

TM's efficacy has also been investigated in animal models of inflammatory and immune-related diseases (24, 25), but clinical studies are needed to evaluate whether copper depletion might stabilize diseases and improve survival in humans, as suggested by a trial of TM therapy with patients with biliary cirrhosis (26)