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Additionally, they can reduce the expression and activity of key iron uptake proteins such as transferrin receptor, divalent metal transporter 1 (DMT1), and zinc-iron transporters, while also modulating critical regulatory factors including iron-regulated proteins and hypoxia-inducible factor 1 (27)

ROS-activation of Apoptosis Signal-regulating Kinase/c-Jun N-terminal kinase/p38 (ASK1-JNK/p38) and Mitogen-Activated Protein Kinase (MAPK), results in cell death