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Two randomized controlled trials in women with hypothalamic amenorrhea have shown conflicting results: one indicated an increase in osteocalcin and N-telopeptides of type 1 collagen (NTX) but no change in BMD [102], while the other revealed increased spine BMD in lean women with hypoleptinemia [101, 103, 104]

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Brzozowski T, Konturek PCh, Sliwowski Z et al

An increase in GBB has also been shown to attenuate the development of endothelial dysfunction, one of the key factors in high-glucose-induced deep vein thrombosis (DVT) 32