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Although paracetamol is safely broken down into harmless byproducts when taken in normal doses, excess use or prolonged usage can produce toxic metabolites like N-acetyl-p-benzoquinone imine (NAPQI) that can cause liver damage and even be fatal

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At higher concentrations, cocaine also blocks different voltage gated channels in a state-dependent manner with a higher affinity for inactivated and open states vs rested/closed states of the channels