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In the trial-product estimand analysis (accounting for treatment adherence), reductions reached 22.7% and 2.3%, respectively, corresponding to an absolute weight loss of -21.6 kg with combination therapy

doi: 10.1371/journal.pone.0022552 13 MaiaALKimBWHuangSAHarneyJWLarsenPR

It is studied primarily for its investigated effects on telomerase activity and telomere biology telomeres being the protective caps on chromosomes that shorten with cellular division and age