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(4) Complex Ferroptosis involves multiple signaling pathways and molecular regulatory networks, including iron metabolism, lipid metabolism, antioxidant system, etc., which reflects the complexity of the ferroptosis pathway and provides a potential target for clinical intervention in related diseases ( Table 1 Overview of cell death types

[80] suggests a potential relationship between increased expression of TGF- and decreased level of GSH in TGF- -mediated fibrogenesis, thus leading to increasing level of ROS