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While various studies have examined the effects of GLP-1 agonists in obesity, two notable phase 3 trials are worth highlighting in this context

Your body produces GLP-1 naturally after you eat, but GLP-1 medications are more reliable forms of the same hormone your body makes, Dr Shah says

Bariatric surgery should be considered in patients with severe obesity, advanced obesity complications, inadequate response to medication, or when durable remission of obesity-related disease is a major treatment goal

How They Work Differently Metformin works primarily by blocking liver glucose production and improving insulin sensitivity, helping the bodys cells absorb glucose more effectively