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The pharma giant cites a report from the Brookings Institute that the FDA has never authorized or approved the manufacturing processes used by any of these foreign suppliers to make semaglutide, nor has the FDA ever reviewed or authorized the quality of the "semaglutide" they produce

Semaglutide vs tirzepatide for weight loss in adults with overweight or obesity

The answer lies in a concept we talk about constantly: bioavailability

Cardiovascular (CV) outcomes were studied in the EXSCEL trial that enrolled adult patients with type 2 diabetes mellitus and multiple risk factors for CV disease or established CV disease [see Clinical Studies (14.5)]