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This led to the discovery of the short gene regulatory regions called antioxidant response elements (AREs) that are required for xenobiotic and oxidative stress-induced expression of phase II detoxification enzymes ( In an effort to identify NRF2 structural domains responsive to oxidative stress and electrophilic compounds, such as sulforaphane, researchers uncovered a novel regulator of NRF2 (Figure 2)

Mishkin, S., Morris, H

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