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real-world studies also suggest higher rates of discontinuation and intermittent use ( 5.2 Rare serious adverse events: individualized screening and monitoring Gallbladder disease: GLP-1RAs are associated with an increased risk of gallbladder-related events, often occurring in parallel with mechanisms such as rapid weight loss and cholestasis ( Pancreatitis and Medullary Thyroid Carcinoma (MTC): while existing evidence has not established a definitive causal link, screening for and avoiding use in patients with a history of pancreatitis, MTC, or a family history of Multiple Endocrine Neoplasia type 2 (MEN2) remains a mandatory precautionary measure (148)

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Renquist, B