Recent Findings Dysregulation of sleep and circadian rhythms has been established in several psychiatric and neurocognitive disorders for long
The exact cause of CFS/ME is unknown, but researchers have identified several potential contributing factors: Immune system abnormalities Impaired energy production in cells Brain abnormalities, such as changes in brain hormones or electrical activity Blood pressure and heart rate irregularities Genetic factors Infections or other illnesses, such as Epstein-Barr virus, Lyme disease, or Q fever Imbalances in brain chemicals, like serotonin, and hormones, like cortisol Diagnosing CFS/ME can be challenging, as there is no specific diagnostic test for the condition
A 2025 pilot study published in PubMed confirmed short-term tolerance in 2 participants at 20mg intravenously, though the sample size remains too limited for definitive safety conclusions
Defects in CI are among the most common causes of mitochondrial disorders and have been linked to a wide range of pathologies, including neurodegenerative and cardiac diseases 28
