While these medications can be effective at helping individuals achieve a healthier body weight, many patients are unaware of an important side effect: the unintended loss of lean muscle mass and bone density
Continued use with monitoring One of the four patients in the Stark case series continued semaglutide and experienced spontaneous resolution of allodynia after approximately four months
Common side effects (10% or more of patients) Nausea Diarrhea Constipation Vomiting Stomach pain or discomfort Indigestion or acid reflux Headache Fatigue or low energy Dizziness Mild injection site reactions (redness, itching, bruising) Serious side effects (rare but require immediate medical attention) Pancreatitis: severe, persistent abdominal pain that may radiate to the back, often with nausea or vomiting Gallbladder problems: upper right abdominal pain, fever, jaundice, or unusual stool color Severe allergic reactions: rash, swelling of the face or throat, difficulty breathing Kidney issues: often related to dehydration from prolonged vomiting or diarrhea Severe hypoglycemia in patients also taking insulin or sulfonylureas Suicidal thoughts or mood changes: contact a healthcare provider promptly Boxed warning: Liraglutide caused thyroid C-cell tumors in animal studies
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