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It is crucial to distinguish between medically indicated B12 replacement therapy and commercially marketed wellness injections, as they serve fundamentally different purposes and are subject to different regulatory oversight

It does not establish that cycling 8 weeks on, 8 weeks off, or any other schedule mitigates any risk

Example: Maria spent $80 on a "metabolic detox kit" promising to "flush toxins released during fat loss." She experienced diarrhea and dehydration, lost no additional weight, and felt considerably worse

Explanation of increases in TE observed at 1 h might be attributed to the higher vascular irrigation