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Specifically, 27 studies found a small positive correlation (a slight association between Tylenol use in pregnancy, particularly during the third trimester, and neurodevelopmental conditions) 9 studies found no association 4 studies found a negative association (Tylenol use during pregnancy is correlated with fewer neurodevelopmental conditions) Importantly, each one of the studies in this review was observational, and, therefore, subject to the effects of confounding variables, such as the reasons mothers took Tylenol in the first place, and other factors, such as genetic or environmental exposures

The extraction and analysis processes followed the same protocol as described for the in vitro studies

These triggers overwhelm the red blood cells' limited defences, causing them to break down prematurely a process known as haemolysis