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Age-associated changes in microglia activation and Sirtuin-1-chromatin binding patterns

As hypothesized, we found the level of total GSH, free GSH, and GSSG to be significantly reduced in the EDTA-treated plasma stored at 4 o C compared to the non-deproteinized EDTA-treated plasma stored at 80 o C (Preparation Condition 3)

Similar to Dpp4 / mice, HFHC-fed control mice ( Dpp4 GFP ) and Dpp4 hep/ mice did not differ in GIR (Figure 1G) or GDR (Figure 1H) or in body weight or fasting glucose (Supplemental Figure 1, C and D)