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Med 21 , 757 (2023)

In the letter, the FDA said the data it has so far isnt enough to fully understand several potential risks tied to the drug, including heart problems such as heart attack and stroke, as well as drug-induced liver injuries

On the other hand, glutathione-mimetic compounds or -glutamylcysteine (-GC), the limiting substrate for GSH biosynthesis, ameliorate brain pathologies and memory deficits in APP/PS1 63,64

These findings suggest involvement of necroptosis signaling in both CP-induced acute and chronic kidney diseases, further making necroptosis a valuable target for therapeutic intervention during CP chemotherapy