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The model of the open state conformation was based on the cryo-EM structure of GLP-1GLP-1RGs (PDB: 5VAI) and the Fab7F38ECD complex of the Fab7F38GLP-1R crystal structure presented here, which were superimposed on their ECDs using PyMOL

However, the effect varies considerably between individualssome experience diarrhoea and increased bowel frequency, whilst others develop constipation

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This review aims to provide a detailed overview of the key molecular mechanisms of LLPS-mediated aggregate formation by PTMs, which will help further the understanding of the pathogenesis and development of ALS therapeutics