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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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To replenish intracellular GSH, cells synthesize GSH in a two-step metabolic pathway centred on the rate-limiting enzyme glutamate cysteine ligase (GCL), which is composed of a catalytic (GCLC) and a regulatory or modifier (GCLM) subunit, and the GSH synthetase (GS) 22

When butyrate binds to free fatty acid receptor 2 (FFAR2) and free fatty acid receptor 3 (FFAR3) on intestinal L cells, it stimulates GLP-1 release