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Rushing can cause discomfort

After 4 weeks at 4 mg, increase to 6 mg weekly, the higher dose from GLORY-2 that produced 14% average weight loss

This reparative effect is mediated, at least in part, through the upregulation and reorganization of key regulatory proteins, most notably protein kinase C (PKC) and the tight junction scaffolding protein zonula occludens-2 (ZO-2), thereby facilitating the reassembly and functional recovery of the tight junction complex (161)

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