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5 Market outlook Eli Lillys oral non-peptide GLP-1RA orforglipron is advancing through the ACHIEVE Phase III program, with Lilly signaling regulatory submissions for obesity in 2025 and type 2 diabetes in 2026, following positive results from both Phase 2 obesity (GZGI) and Phase 3 T2DM (ACHIEVE-1) trials

For individuals with IBS, this slower digestion can sometimes be beneficial, potentially reducing gut sensitivity and potentially leading to more regulated gut function

Currently, Madrigal Pharmaceuticals Rezdiffra, approved in 2024, is the only other FDA-cleared treatment for MASH, as reported by Reuters

International Evidencebased for the Assessment and management of Polycystic Ovary Syndrome