Take these steps in order: Tell your prescribing doctor what changed and when Reach out to a hearing care provider for an evaluation Never stop a prescribed medication on your own Ask whether a dose change or a different drug is possible Early action gives you the best chance to keep the hearing you have
Additionally, novel compounds such as the SERMs/SERDs hybrid bazedoxifene and the selective ER covalent antagonists are undergoing phase 2 clinical trials for patients experiencing disease progression following advanced endocrine therapy
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A 2024 retrospective cohort analysis published in Diabetes, Obesity and Metabolism (N=312 patients who switched from semaglutide to tirzepatide at a single academic center) found that switchers lost an additional mean of 6.3% of body weight over 6 months after the switch, with 68% reporting either stable or improved GI tolerability [12]